Aldehyde Oxidase Importance In Vivo in Xenobiotic Metabolism: Imidacloprid Nitroreduction in Mice

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Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice.

Aldehyde oxidase (AOX) metabolizes many xenobiotics in vitro, but its importance in vivo is usually unknown relative to cytochrome P450s (CYPs) and other detoxification systems. Currently, the most important insecticides are neonicotinoids, which are metabolized in vitro by AOX on reduction of the nitroimino group and by CYPs via oxidation reactions. The goal of this study was to establish the ...

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Short Communication Aldehyde Oxidase-Catalyzed Metabolism of N-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

Aldehyde oxidase-mediated oxidation of N-methylnicotinamide to N-methyl-2-pyridine-5-carboxamide (2-PY) and N-methyl-4pyridone-5-carboxamide (4-PY) in chimeric mice constructed by transplanting human hepatocytes into urokinase-type plasminogen activator-transgenic severe combined immunodeficient mice was examined in vivo and in vitro. The activity in liver cytosol of chimeric mice with a high r...

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Short Communication Aldehyde Oxidase-Catalyzed Metabolism of N-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

Aldehyde oxidase-mediated oxidation of N-methylnicotinamide to N-methyl-2-pyridine-5-carboxamide (2-PY) and N-methyl-4pyridone-5-carboxamide (4-PY) in chimeric mice constructed by transplanting human hepatocytes into urokinase-type plasminogen activator-transgenic severe combined immunodeficient mice was examined in vivo and in vitro. The activity in liver cytosol of chimeric mice with a high r...

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Short Communication Aldehyde Oxidase-Catalyzed Metabolism of N-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

Aldehyde oxidase-mediated oxidation of N-methylnicotinamide to N-methyl-2-pyridine-5-carboxamide (2-PY) and N-methyl-4pyridone-5-carboxamide (4-PY) in chimeric mice constructed by transplanting human hepatocytes into urokinase-type plasminogen activator-transgenic severe combined immunodeficient mice was examined in vivo and in vitro. The activity in liver cytosol of chimeric mice with a high r...

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ژورنال

عنوان ژورنال: Toxicological Sciences

سال: 2013

ISSN: 1096-0929,1096-6080

DOI: 10.1093/toxsci/kft066